Mission glitch:
In Clockwork, I came across a game-breaking glitch where after entering the lab and yelling at the civilians to get out, Merric/Keegan (can't remember which it was) freezes in a T-pose, floating several feet above the ground.
I was then prompted to put my bag on the table, and when I did the camera locked up I couldn't move, shoot, or do anything except pause.
I reloaded from the last checkpoint three times, and all three times the same glitch occurred.